The technology identifies the usage of antibodies to recognize cells that express the BFA4 protein, aswell for the medical diagnosis, prevention, and/or treatment of 1 or even more diseases related to the existence of such cells, like ovarian, lung and renal cancer, biliary and pancreatic cancer, T and B cell lymphoma, colon carcinoma, and hepatocarcinoma

The technology identifies the usage of antibodies to recognize cells that express the BFA4 protein, aswell for the medical diagnosis, prevention, and/or treatment of 1…

N-((S)-4-(Benzylamino)-3-((S)-2-(3-(1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-yl)ureido)-3-(3,4-difluorophenyl)propanamido)-4-oxobutyl)pent-4-ynamide (12, DG-207) Notice If using 11b, it is necessary to convert this compound to the bis HCl salt (11a) prior to performing this EDC coupling reaction as it has been seen the formate salt will give a mixture of products

N-((S)-4-(Benzylamino)-3-((S)-2-(3-(1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-yl)ureido)-3-(3,4-difluorophenyl)propanamido)-4-oxobutyl)pent-4-ynamide (12, DG-207) Notice If using 11b, it is necessary to convert this compound to the bis HCl salt (11a) prior to performing this EDC…

CTLA\4, cytotoxic T\lymphocyteCassociated protein 4; Foxp3, forkhead protein 3; GARP, glycoprotein A repetitions predominant; HLA\DR, human leukocyte antigen\DR isotype; nR, non\responder; PD\1, programmed cell death protein 1; R, responder; Treg, regulatory T cells To quantify the T cell\to\Treg composition in the peripheral blood, we calculated the corresponding T cell\to\Treg ratios

CTLA\4, cytotoxic T\lymphocyteCassociated protein 4; Foxp3, forkhead protein 3; GARP, glycoprotein A repetitions predominant; HLA\DR, human leukocyte antigen\DR isotype; nR, non\responder; PD\1, programmed cell death…