These are understandable due to the following reasons: (1) the ligand imatinib is a very weak polar molecule, which results in that the ligand suffers very similar electrostatic connection when dissociating through different pathways; (2) hydrogen bonds are usually in the programs of breaking and forming in the ligand unbinding process, and the overall quantity of hydrogen bonds keep relatively invariable

These are understandable due to the following reasons: (1) the ligand imatinib is a very weak polar molecule, which results in that the ligand suffers…